INCREASED LEVELS OF NGF IN SERA OF SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS

被引：121

作者：

BRACCILAUDIERO, L

ALOE, L

LEVIMONTALCINI, R

GALEAZZI, M

SCHILTER, D

SCULLY, JL

OTTEN, U

机构：

[1] UNIV BASEL, DEPT PHYSIOL, VESALGASSE 1, CH-4051 BASEL, SWITZERLAND

[2] CNR, INST NEUROBIOL, ROME, ITALY

[3] UNIV SIENA, DEPT PHYSIOL, I-53100 SIENA, ITALY

来源：

NEUROREPORT | 1993年 / 4卷 / 05期

关键词：

SYSTEMIC LUPUS ERYTHEMATOSUS; NERVE GROWTH FACTOR; ELISA; AUTOIMMUNITY;

D O I：

10.1097/00001756-199305000-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

USING a specific enzyme-linked immunosorbent assay (ELISA) for human nerve growth factor (NGF), serum levels in patients with systemic lupus erythematosus (SLE) were measured. We found a consistent increase in NGF levels in SLE patients compared with controls. A good correlation exists between serum NGF level and severity of clinical manifestation. We hypothesize that NGF might play a role in the pathogenesis of autoimmune disorders such as SLE.

引用

页码：563 / 565

页数：3

共 25 条

[1] NERVE GROWTH-FACTOR IN THE SYNOVIAL-FLUID OF PATIENTS WITH CHRONIC ARTHRITIS [J].