RETROVIRAL SEQUENCES RELATED TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-II IN PATIENTS WITH CHRONIC FATIGUE IMMUNE DYSFUNCTION SYNDROME

被引：125

作者：

DEFREITAS, E

HILLIARD, B

CHENEY, PR

BELL, DS

KIGGUNDU, E

SANKEY, D

WROBLEWSKA, Z

PALLADINO, M

WOODWARD, JP

KOPROWSKI, H

机构：

[1] Wistar Institute, Philadelphia, PA 19104

[2] Charlotte, NC 28210

[3] Lyndonville, NY 14098

[4] Philadelphia, PA 19120

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 07期

关键词：

EPSTEIN-BARR VIRUS SYNDROME; INFECTIOUS MONONUCLEOSIS; MYALGIC ENCEPHALOMYELITIS; POLYMERASE CHAIN REACTION; INSITU HYBRIDIZATION;

D O I：

10.1073/pnas.88.7.2922

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic fatigue immune dysfunction syndrome (CFIDS) is a recently recognized illness characterized by debilitating fatigue as well as immunological and neurological abnormalities [Straus, S. E. (1988) J. Inf. Dis. 157, 405-412]. Once thought to be caused by Epstein-Barr virus, it is now thought to have a different but unknown etiology. We evaluated 30 adult and pediatric CFIDS patients from six eastern states for the presence of human T-lymphotropic virus (HTLV) types I and II by Western immunoblotting, polymerase chain reaction, and in situ hybridization of blood samples. The majority of patients were positive for HTLV antibodies by Western blotting and for HTLV-II gag sequences by polymerase chain reaction and in situ hybridization. Twenty nonexposure healthy controls were negative in all assays. These data support an association between an HTLV-II-like virus and CFIDS.

引用

页码：2922 / 2926

页数：5

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