MACROPOROUS CALCIUM-PHOSPHATE CERAMICS FOR BONE SUBSTITUTION - A TRACER STUDY ON BIODEGRADATION WITH CA-45 TRACER

The value of artifical materials in bone replacement depends highly on their biocompatibility and biostability. Porous calcium phosphate ceramics have a good compatibility with natural bone. To study the biodegradation process of calcium phosphate bioceramics, labelled [Ca-45]-beta-whitlockite and [Ca-45]-hydroxyapatite were implanted in the femurs of dogs. The effects accompanying the ingrowth of new bone into the pores of these bioceramics and its replacement by natural bone were investigated. In vivo degradation of the implant material by biochemical dissolution processes was observed. The beta-whitlockite implants showed a conspicuous decrease in radioactive calcium, in contrast to the hydroxyapatite implants. Ca-45 was absent in adjacent bones and locally newly formed bone in both beta-whitlockite and hydroxyapatite suggesting a restricted availability of the Ca-45 liberated in these processes. Indications of minor mechanical degradation of the materials were also found; in the lymph nodes a very small amount of Ca-45 with a high specific activity was detectable. Urine, blood or faeces contained no detectable amounts of Ca-45 activity.