SUCCESSIVE LECTIN-BINDING CHANGES WITHIN THE COLLECTING DUCT DURING POSTNATAL-DEVELOPMENT OF THE RABBIT KIDNEY

被引：12

作者：

MINUTH, WW

RUDOLPH, U

机构：

[1] Institute of Anatomy, University of Regensburg, Regensburg, D-8400

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 05期

关键词：

RABBIT KIDNEY; COLLECTING DUCT; MORPHOLOGICAL MATURATION; HISTOCHEMICAL MATURATION; LECTINS;

D O I：

10.1007/BF00869833

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Histological sections of neonatal rabbit kidney of various ages were analysed to study the ontogeny of the collecting duct system. In addition, the sections were incubated with fluorescent wheat germ (WGA) and peanut agglutinin (PNA) to investigate the terminal differentiation of collecting duct cells. With both lectins we found different binding behaviours in the three segments of the collecting duct anlagen, the ampullary bud, the ampullary neck and the collecting duct. During the observed steps in development the lectin-binding pattern in the collecting duct and the ampullary neck appeared unchanged. In the collecting duct most cells reacted with WGA and only a few with PNA, while in the ampullary neck all cells bound both WGA and PNA. In the ampullary bud, however, the lectin-binding pattern changed between unlabelled and completely labelled stages with both lectins. The results indicate that both intercalated and principal cells originate from a common precursor cell.

引用

页码：505 / 509

页数：5

共 18 条

[1]

Madsen K.M., Tisher C.C., Structural-functional relationship along the distal nephron, Am J Physiol, 250, pp. F1-F15, (1986)

[2]

Kriz W., Bankir L., A standard nomenclature for structures of the kidney, Pflugers Arch, 411, pp. 113-120, (1988)

[3]

Kriz W., Kaissling B., Structural organization of the mammalian kidney, The kidney: physiology and pathophysiology, pp. 265-306, (1985)

[4]

Schuster V.L., Bonsib S.M., Jennings M.L., Two types of collecting duct mitochondria-rich (intercalated) cells: lectin and band 3 cytochemistry, Am J Physiol, 251, pp. C347-C355, (1986)

[5]

Holthofer H., Schulte B.A., Pasternack G., Siegel G.J., Spicer S.S., Immunocytochemical characterization of carbonic anhydrase-rich cells in the rat kidney collecting duct, Lab Invest, 57, pp. 150-156, (1987)

[6]

Schwartz G.J., Satlin L.M., Bergmann J.E., Fluorescent characterization of collecting duct cells: a second H-secreting type, Am J Physiol, 255, pp. F1003-F1014, (1988)

[7]

Saxen L., Organogenesis of the kidney, Developmental and cell biology series 19, (1987)

[8]

Minuth W.W., Gilbert P., Lauer G., Aktories K., Gross P., Differentiation properties of renal collecting duct cells in culture, Differentiation, 33, pp. 156-167, (1986)

[9]

Minuth W.W., Gross P., Gilbert P., Kashgarian M., Expression of the α-subunit of Na/K-ATPase in renal collecting duct epithelium during development, Kidney Int, 31, pp. 1104-1112, (1987)

[10]

Laitinen L., Virtanen I., Saxen L., Changes in the glycosylation pattern during embryonic development of mouse kidney as revealed with lectin conjugates, J Histochem Cytochem, 35, pp. 55-65, (1987)

← 1 2 →