EFFECTS OF AEROSOL ADMINISTRATION OF A THROMBOXANE RECEPTOR ANTAGONIST (S-1452) ON EXPERIMENTAL ASTHMA IN GUINEA-PIGS

被引：4

作者：

SAITO, M

FUJIMURA, M

MIZUHASHI, K

SHINTANI, H

MATSUDA, T

机构：

[1] Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa

来源：

ALLERGY | 1994年 / 49卷 / 08期

关键词：

GUINEA PIGS; HISTAMINE; IMMEDIATE ASTHMATIC REACTION; S-1452; THROMBOXANE A(2);

D O I：

10.1111/j.1398-9995.1994.tb00142.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The importance of thromboxane A(2) (TXA(2)), one of the arachidonate metabolites, in the pathogenesis of bronchial asthma has been emphasized recently. Because aerosolized administration of antiasthmatic drugs is effective and safe, this study examined the effect of aerosolized TXA, receptor antagonist (S-1542) on allergic bronchoconstriction in passively sensitized and mechanically ventilated guinea pigs. Under the cover of antihistamine, antigen-induced bronchoconstriction was markedly inhibited by pretreatment with aerosolized S-1452 inhalation in a dose-dependent manner. Although aerosolized S-1452 itself provoked weak bronchoconstriction for its partial agonist effect, bronchial responsiveness to inhaled histamine did not change 10 min after S-1452 inhalation. These results indicate that aerosolized S-1452 may be useful in treating bronchial asthma.

引用

页码：680 / 684

页数：5

共 19 条

[1]

ARIMURA A, 1991, Journal of Allergy and Clinical Immunology, V87, P254, DOI 10.1016/0091-6749(91)91742-C

[2] S-1452 - A NOVEL TXA(2) RECEPTOR ANTAGONIST [J].