SYNTHESIS OF N-(2-CARBOXY-THIENO[2,3-B]PYRIDINE-3-YL)-FORMAMIDINES AND CORRESPONDING ALKYL ESTERS WITH ANTIANAPHYLACTIC ACTIVITY

被引：0
|
作者：
WAGNER, G
VIEWEG, H
PRANTZ, J
LEISTNER, S
机构：
来源：
PHARMAZIE | 1993年 / 48卷 / 03期
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A lot of N-(2-carboxy-thieno[2,3-b]pyridin-3-yl)formamidines especially in form of their amine salts - were synthesized by reaction of 3-amino-thieno[2,3-b]pyridine-2-carboxylic acids with dimethylformamide/phosphoroxide chloride or by reaction of 4-oxo-4 H-pyrido[3',2':4,5]thieno[3,2-d]1,3-oxazines with amines. Carboxylic acid alkylesters of this structure were yielded from 3-amino-thieno[2,3-b]pyridine-2-carbonic acid alkylesters by reaction with dimethylformamide/phosphoroxide chloride or with N-formyl-piperidine or N-formyl-morpholine and phosphoroxide chloride. The compounds showed antianaphylactic activity.
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页码：185 / 188
页数：4
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