Effect of valproic acid usage on serum protein and immuneglobulin levels in epileptic patients

Purpose: The aim of this study was to research the possible effect of VPA usage on serum protein and immunoglobulin (Ig) levels in epileptic patients. Material and methods: Twenty-five patients followed up after being diagnosed with epilepsy for a minimum of 6 months and were treated with VPA formed the experimental group. In all cases, serum protein and Ig levels, as well as VPA levels were measured. It has been investigated that in VPA using group whether serum protein and Ig levels affected VPA usage doses, treatment period, and levels in addition to the age and sex distribution. Results: There was no statistically significant difference in total protein, albumin, and Ig levels between VPA treatment and control groups. It was determined that in the epileptic group serum protein, albumin, Ig A, M, and G levels were not affected by the VPA serum levels, dosage or treatment duration or age and gender. Conclusion: While the treatment of VPA on epileptic patients, which requires long term usage, a regular follow up for serum proteins and immunoglobulins should be done and because of different results in different studies we suggest that more extensive studies should be performed for the definite results.