NEW MEMBER OF THE WINGED-HELIX PROTEIN FAMILY DISRUPTED IN MOUSE AND RAT NUDE MUTATIONS

被引：553

作者：

NEHLS, M

PFEIFER, D

SCHORPP, M

HEDRICH, H

BOEHM, T

机构：

[1] HANNOVER MED SCH,ZENT TIERVERSUCHSANLAGE,D-30625 HANNOVER,GERMANY

[2] UNIV FREIBURG,DEPT MED 1,MOLEC MED GRP,D-79106 FREIBURG,GERMANY

来源：

NATURE | 1994年 / 372卷 / 6501期

关键词：

D O I：

10.1038/372103a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MUTATIONS at the nude locus of mice and rats disrupt normal hair growth and thymus development(1,2), causing nude mice and rats to be immune-deficient. The mouse nude locus has been localized on chromosome 11 (refs 3, 4) within a region of <1 megabase(5). Here we show that one of the genes from this critical region, designated whn, encodes a new member of the winged-helix domain family of transcription factors(6.7), and that it is disrupted on mouse au and rat rnuN alleles. Mutant transcripts do not encode the characteristic DNA-binding domain, strongly suggesting that the whn gene is the nude gene. Mutations in winged-helix domain genes cause homeotic transformations in Drosophila(8) and distort cell-fate decisions during vulval development in Caenorhabditis elegans(9). The whn gene is thus the first member of this class of genes to be implicated in a specific developmental defect in vertebrates.

引用

页码：103 / 107

页数：5

共 21 条

[1] THE RHOMBOTIN FAMILY OF CYSTEINE-RICH LIM-DOMAIN ONCOGENES - DISTINCT MEMBERS ARE INVOLVED IN T-CELL TRANSLOCATIONS TO HUMAN CHROMOSOME-11P15 AND CHROMOSOME-11P13 [J].