IRREVERSIBLE ENZYME-INHIBITORS .196. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE DERIVED FROM 1-(4-BENZYLOXY-3-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE AND BEARING A TERMINAL PHENYL SULFONATE GROUP

被引：11

作者：

BAKER, BR

ASHTON, WT

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1972年 / 15卷 / 09期

关键词：

D O I：

10.1021/jm00279a017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：945 / &

共 15 条

[1] IRREVERSIBLE ENZYME INHIBITORS .113. PROTEOLYTIC ENZYMES .3. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF ALPHA-CHYMOTRYPSIN DERIVED FROM PHENOXYACETAMIDES WITH AN N-FLUOROSULFONYLPHENYL SUBSTITUENT [J].

BAKER, BR ;

HURLBUT, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (02) :233-&

[2] IRREVERSIBLE ENZYME INHIBITORS .179. ACTIVE-SITE-DIRECTEC IRREVERSIBLE ENZYME INHIBITORS OF DIHYDROFOLATE REDUCTASE FROM 1-(3-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE WITH OXYAMIDE BRIDGES TO A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

ASHTON, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1165-&

[3] IRREVERSIBLE ENZYME INHIBITORS .178. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE DERIVED FROM 1-(4-BENZYLOXY-3-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE WITH A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

ASHTON, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1161-&

[4] IRREVERSIBLE ENZYME INHIBITORS .176. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE BY ETHER BRIDGING TO A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

ASHTON, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1149-&

[5] IRREVERSIBLE ENZYME INHIBITORS .175. IRREVERSIBLE INHIBITION OF PURIFIED DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1143-+

[6] IRREVERSIBLE ENZYME INHIBITORS . 133 . STUDIES ON DIFFERENTIAL IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM 3 STRAINS OF L1210 LEUKEMIA LIVER SPLEEN AND INTESTINE OF MOUSE [J].

BAKER, BR ;

LOURENS, GJ ;

MEYER, RB ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :67-+

[7] IRREVERSIBLE ENZYME INHIBITORS .129. P-(4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZIN-1-YL)PHENYLPROPIONYLSULFANILYL FLUORIDE AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE .V. EFFECTS OF SUBSTITUTION ON BENZENESULFONYL FLUORIDE MOIETY ON ISOZYME SPECIFICITY [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (04) :677-&

[8] IRREVERSIBLE ENZYME INHIBITORS .177. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE DERIVED FROM 4,6-DIAMINO-1, - DIHYDRO-2,2-DIMETHYL-1-(PHENYLALKYLPHENYL)-S-TRIAZINES .2. [J].

BAKER, BR ;

VERMEULEN, NM .

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[9]

BAKER BR, 1972, J MED CHEM, V15, P195

[10]

Baker BR, 1967, DESIGN ACTIVE SITE D

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