HORIZONTAL SPREAD OF AN ALTERED PENICILLIN-BINDING PROTEIN 2B GENE BETWEEN STREPTOCOCCUS-PNEUMONIAE AND STREPTOCOCCUS-ORALIS

被引：55

作者：

COFFEY, TJ ^{[1
]}

DOWSON, CG ^{[1
]}

DANIELS, M ^{[1
]}

SPRATT, BG ^{[1
]}

机构：

[1] UNIV SUSSEX,SCH BIOL SCI,MICROBIAL GENET GRP,BRIGHTON BN1 9QG,E SUSSEX,ENGLAND

来源：

FEMS MICROBIOLOGY LETTERS | 1993年 / 110卷 / 03期

基金：

英国惠康基金;

关键词：

HORIZONTAL GENE TRANSFER; INTERSPECIES TRANSFER; PENICILLIN RESISTANCE; STREPTOCOCCI;

D O I：

10.1016/0378-1097(93)90125-L

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The region encoding the transpeptidase domain of the penicillin-binding protein 2B (PBP 2B) gene of two penicillin-resistant clinical isolates of Streptococcus oralis was > 99.6% identical in nucleotide sequence to that of a penicillin-resistant serotype 6 isolate of Streptococcus pneumoniae. The downstream 849 base pairs of these genes were identical. Analysis of the data indicates that the PBP gene has probably been transferred from S. pneumoniae into S. oralis, rather than vice versa, and shows that one region of this resistance gene has been distributed horizontally both within S. pneumoniae and into two different viridans group streptococci.

引用

页码：335 / 339

页数：5

共 18 条

[1] ANTIMICROBIAL RESISTANCE IN STREPTOCOCCUS-PNEUMONIAE - AN OVERVIEW [J].

APPELBAUM, PC .

CLINICAL INFECTIOUS DISEASES, 1992, 15 (01) :77-83

[2] A SCHEME FOR THE IDENTIFICATION OF VIRIDANS STREPTOCOCCI [J].

BEIGHTON, D ;

HARDIE, JM ;

WHILEY, RA .

JOURNAL OF MEDICAL MICROBIOLOGY, 1991, 35 (06) :367-372

[3] INTRA-SPECIFIC AND INTER-SPECIFIC TRANSFORMATION OF STREPTOCOCCUS-PNEUMONIAE TO PENICILLIN RESISTANCE [J].

CHALKLEY, LJ ;

KOORNHOF, HJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 26 (01) :21-28

[4] HORIZONTAL TRANSFER OF MULTIPLE PENICILLIN-BINDING PROTEIN GENES, AND CAPSULAR BIOSYNTHETIC GENES, IN NATURAL-POPULATIONS OF STREPTOCOCCUS-PNEUMONIAE [J].

COFFEY, TJ ;

DOWSON, CG ;

DANIELS, M ;

ZHOU, J ;

MARTIN, C ;

SPRATT, BG ;

MUSSER, JM .

MOLECULAR MICROBIOLOGY, 1991, 5 (09) :2255-2260

[5] HORIZONTAL TRANSFER OF PENICILLIN-BINDING PROTEIN GENES IN PENICILLIN-RESISTANT CLINICAL ISOLATES OF STREPTOCOCCUS-PNEUMONIAE [J].

DOWSON, CG ;

HUTCHISON, A ;

BRANNIGAN, JA ;

GEORGE, RC ;

HANSMAN, D ;

LINARES, J ;

TOMASZ, A ;

SMITH, JM ;

SPRATT, BG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8842-8846

[6] PENICILLIN-RESISTANT VIRIDANS STREPTOCOCCI HAVE OBTAINED ALTERED PENICILLIN-BINDING PROTEIN GENES FROM PENICILLIN-RESISTANT STRAINS OF STREPTOCOCCUS-PNEUMONIAE [J].

DOWSON, CG ;

HUTCHISON, A ;

WOODFORD, N ;

JOHNSON, AP ;

GEORGE, RC ;

SPRATT, BG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5858-5862

[7] NUCLEOTIDE-SEQUENCE OF THE PENICILLIN-BINDING PROTEIN-2B GENE OF STREPTOCOCCUS-PNEUMONIAE STRAIN-R6 [J].

DOWSON, CG ;

HUTCHISON, A ;

SPRATT, BG .

NUCLEIC ACIDS RESEARCH, 1989, 17 (18) :7518-7518

[8] MULTIPLY RESISTANT VIRIDANS STREPTOCOCCI - SUSCEPTIBILITY TO BETA-LACTAM ANTIBIOTICS AND COMPARISON OF PENICILLIN-BINDING PROTEIN-PATTERNS [J].

FARBER, BF ;

ELIOPOULOS, GM ;

WARD, JI ;

RUOFF, KL ;

SYRIOPOULOU, V ;

MOELLERING, RC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 24 (05) :702-705

[9] PENICILLIN-BINDING PROTEINS OF PENICILLIN-SUSCEPTIBLE AND PENICILLIN-RESISTANT PNEUMOCOCCI - IMMUNOLOGICAL RELATEDNESS OF ALTERED PROTEINS AND CHANGES IN PEPTIDES CARRYING THE BETA-LACTAM BINDING-SITE [J].

HAKENBECK, R ;

ELLERBROK, H ;

BRIESE, T ;

HANDWERGER, S ;

TOMASZ, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (04) :553-558

[10] DIRECT SOLID-PHASE SEQUENCING OF GENOMIC AND PLASMID DNA USING MAGNETIC BEADS AS SOLID SUPPORT [J].

HULTMAN, T ;

STAHL, S ;

HORNES, E ;

UHLEN, M .

NUCLEIC ACIDS RESEARCH, 1989, 17 (13) :4937-4946

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