BETA-ALANINE, LIKE GLYCINE, MICROINJECTED INTO THE RAT NUCLEUS-TRACTUS-SOLITARII INCREASES BLOOD-PRESSURE

被引：7

作者：

KUBO, T

KIHARA, M

机构：

[1] Department of Pharmacology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama 236, Fukuura

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE | 1990年 / 12卷 / 08期

关键词：

NUCLEUS-TRACTUS-SOLITARIUS; BETA-ALANINE; GLYCINE; AORTIC NERVE; BLOOD PRESSURE; RAT;

D O I：

10.3109/10641969009073523

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Microinjections of beta-alanine and glycine into the nucleus tractus solitarii (NTS) of the rat, led to an increase in blood pressure and heart rate. The responses to glycine but not to beta-alanine could be blocked by strychnine. Both amino acids reduced the responses to aortic nerve stimulation. High K+ stimulation caused a calcium-dependent release of beta-alanine from tissues in the area of the NTS. These results suggest that beta-alanine and glycine may modulate the cardiovascular control within the NTS.

引用

收藏

页码：1351 / 1360

页数：10

相关论文

共 16 条

[1] A GAMMA-AMINOBUTYRIC-ACID-MEDIATED INHIBITION OF NEURONS IN THE NUCLEUS TRACTUS SOLITARIUS OF THE CAT [J].

BENNETT, JA ;

MCWILLIAM, PN ;

SHEPHEARD, SL .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 392 :417-430

[2] EVIDENCE FOR A NEUROMODULATORY ROLE OF GABA AT THE 1ST SYNAPSE OF THE BARORECEPTOR REFLEX PATHWAY - EFFECTS OF GABA DERIVATIVES INJECTED INTO THE NTS [J].

BOUSQUET, P ;

FELDMAN, J ;

BLOCH, R ;

SCHWARTZ, J .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1982, 319 (02) :168-171

[3] GABAERGIC MECHANISMS IN NUCLEUS TRACTUS SOLITARIUS ALTER BLOOD-PRESSURE AND VASOPRESSIN RELEASE [J].

CATELLI, JM ;

GIAKAS, WJ ;

SVED, AF .

BRAIN RESEARCH, 1987, 403 (02) :279-289

[4] BRAIN-STEM PROJECTIONS OF AORTIC BARORECEPTOR AFFERENT-FIBERS IN THE RAT [J].

CIRIELLO, J .

NEUROSCIENCE LETTERS, 1983, 36 (01) :37-42

[5]

JORDAN D, 1988, J PHYSIOL-LONDON, V399, P389

[6] BIOCHEMISTRY OF NEUROTRANSMITTER RELEASE [J].

KELLY, RB ;

DEUTSCH, JW ;

CARLSON, SS ;

WAGNER, JA .

ANNUAL REVIEW OF NEUROSCIENCE, 1979, 2 :399-446

[7] RELEASE BY ELECTRICAL-STIMULATION OF ENDOGENOUS GLUTAMATE, GAMMA-AMINOBUTYRIC ACID, AND OTHER AMINO-ACIDS FROM SLICES OF THE RAT MEDULLA-OBLONGATA [J].

KIHARA, M ;

MISU, Y ;

KUBO, T .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (01) :261-267

[8] ALTERED AMINO-ACID LEVELS IN BRAIN-STEM REGIONS OF SPONTANEOUSLY HYPERTENSIVE RATS [J].

KUBO, T ;

KIHARA, M ;

MISU, Y .

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1989, 11 (02) :233-241

[9] EVIDENCE FOR GAMMA-AMINOBUTYRIC ACID RECEPTOR-MEDIATED MODULATION OF THE AORTIC BARORECEPTOR REFLEX IN THE NUCLEUS TRACTUS SOLITARII OF THE RAT [J].

KUBO, T ;

KIHARA, M .

NEUROSCIENCE LETTERS, 1988, 89 (02) :156-160

[10] VASOPRESSIN-INDUCED PRESSOR-RESPONSES IN RATS TO BILATERAL ELECTROLYTIC LESIONING OF THE CAUDAL PORTION OF THE NUCLEUS TRACTUS SOLITARII [J].

KUBO, T ;

AMANO, H .

BRAIN RESEARCH, 1986, 363 (01) :183-187