ACTION OF DI-IODOBENZOTEPA ON FUNCTIONALLY DIFFERENT LYMPHOCYTE-T SUB-POPULATIONS

被引：0

作者：

DRANNIK, GN

MANKO, VM

PETROV, RV

SOLOGUB, PY

SHARYKINA, NI

机构：

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1979年 / 88卷 / 10期

关键词：

di-iodobenzotepa; T-helpers; T-suppressors;

D O I：

10.1007/BF00838188

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Di-iodobenzotepa (DIB) was given per os daily for 3 days in a dose of 25 mg/kg to CBA mice. A decrease in the number of nucleated cells in the thymus by 74% and in the bone marrow by 29% was observed. Experiments with transplantation of lymphocytes from mice treated with DIB into intact or lethally irradiated (CBAxC57BL/6J)F1 mice showed that DIB has no effect on the helper activity of T-lymphocytes but depresses the functional activity of B-lymphocytes and t-lymphocytes, inducing the graft versus host reaction, and of T-suppressor cells. © 1980 Plenum Publishing Corporation.

引用

页码：1141 / 1143

页数：3