THE GENE FOR INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 IS LOCALIZED TO HUMAN CHROMOSOMAL REGION 7P14-P12

被引：16
作者：
EKSTRAND, J
EHRENBORG, E
STERN, I
STELLAN, B
ZECH, L
LUTHMAN, H
机构：
[1] KAROLINSKA INST,DEPT CLIN GENET,S-10401 STOCKHOLM 60,SWEDEN
[2] KAROLINSKA INST,DEPT MED CELL GENET,S-10401 STOCKHOLM 60,SWEDEN
来源：
GENOMICS | 1990年 / 6卷 / 03期
关键词：
D O I：
10.1016/0888-7543(90)90470-F
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Insulin-like growth factors (IGF) I and II are bound to high-affinity binding proteins in the blood circulation and other body fluids. These IGF-binding proteins are expressed at different concentrations in different tissues and are thought to regulate the activity of IGF I and II. Cloned cDNA for IGF-binding protein-1 (IGFBP1) has been used to verify the location of its gene to human chromosome 7 by Southern blotting to DNA from a human-mouse hybrid cell line. Further, by in situ hybridization the gene was regionally localized to 7p14-p12, and a Mendelian-inherited two-allele BglII restriction enzyme length polymorphism was identified, with the most frequent allele occurring in 53% of the chromosomes. © 1990.
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页码：413 / 418
页数：6
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