GLIAL FIBRILLARY ACIDIC PROTEIN AND INTERMEDIATE FILAMENTS IN HUMAN GLIOMA-CELLS

被引:86
作者
PAETAU, A
VIRTANEN, I
STENMAN, S
KURKI, P
LINDER, E
VAHERI, A
WESTERMARK, B
DAHL, D
HALTIA, M
机构
[1] UNIV HELSINKI, DEPT SEROL & BACTERIOL, SF-00290 HELSINKI 29, FINLAND
[2] UNIV HELSINKI, DEPT VIROL, SF-00290 HELSINKI, FINLAND
[3] UNIV UPPSALA, WALLENBERG LAB, S-75105 UPPSALA, SWEDEN
[4] HARVARD UNIV, SCH MED, DEPT NEUROPATHOL, BOSTON, MA 02115 USA
关键词
Glial cells; Glial fibrillary acidic protein; Intermediate filaments;
D O I
10.1007/BF00698276
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cultured human glioma cells were studied by double indirect immunofluorescence technique using antisera against intermediate filaments and glial fibrillary acidic protein. With both antisera cytoplasmic fibrillar fluorescence was seen. Perinuclear bundles of intermediate-sized filaments, induced by vinblastine treatment, were strongly stained with both antisera. The degree of codistribution of the two types of antigenic determinants varied considerably from cell to cell. These results suggest that two types of filament-related antigenic determinants can be present in the same cell, and also that glial fibrillary acidic protein-related filaments may possess functional similarities to the intermediate filaments found in other cells. Glial fibrillary acidic protein remains as a useful and specific antigenic marker for the study of glial cells in vitro. © 1979 Springer-Verlag.
引用
收藏
页码:71 / 74
页数:4
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