PHYSIOLOGIC SURFACE-ACTIVE AGENTS AND DRUG ABSORPTION .I. EFFECT OF SODIUM TAURODEOXYCHOLATE ON SALICYLATE TRANSFER ACROSS EVERTED RAT INTESTINE

被引：67

作者：

FELDMAN, S

GIBALDI, M

机构：

[1] Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 04期

关键词：

Colorimetric analysis—spectrophotometer; Everted rat intestine—experimental technique; Salicylate transfer—Na taurodeoxycholate effect; Serosal; mucosal response—Na taurodeoxycholate; Surfactants; physiologic—drug absorption effect;

D O I：

10.1002/jps.2600580407

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sodium taurodeoxycholate (STDC) increases the permeability of the everted intestine to salicylate. There appear to be two levels of effects; a small effect (30 to 50 percent increase in salicylate‐transfer rates) at concentrations of STDC below or about the CMC and a more pronounced effect (100 to 125 percent increase in transfer rates) at concentrations of STDC above the CMC. Each level of effect is significantly different from control values and from each other but there is no significant concentration dependence within a given level. There is evidence that the site of the bile salt effect is more accessible from the serosal side of everted intestinal preparations than from the mucosal side. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：425 / +

页数：1

共 19 条

[1]

BENET LZ, 1967, 114 ANN M APHA LAS V

[2] INVITRO METHOD FOR THE STUDY OF THE RATE OF INTESTINAL ABSORPTION OF SUGARS [J].