CHEMICAL MECHANISMS OF ALCOHOLIC EFFECTS

被引：17

作者：

BRINGMANN, G

机构：

[1] Organisch-chemisches Institut der Universität, Münster

来源：

NATURWISSENSCHAFTEN | 1979年 / 66卷 / 01期

关键词：

D O I：

10.1007/BF00369351

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The formation of tetrahydro-isoquinoline alkaloids in human and animal metabolisms subsequent to alcohol consumption is reported. The spectrum of identified products ranges from simple structures such as salsolinol to the complicated skeleton of protoberberines. These substances, hitherto found exclusively in plants, interfere with the biosynthesis, biodegradation and neurotransmission of the structurally closely related biogenic amines from which they are formed, and thus affect the vegetative nervous system. © 1979 Springer-Verlag.

引用

页码：22 / 27

页数：6

共 59 条

[1] INHIBITION OF CATECHOLAMINE UPTAKE AND RETENTION IN SYNAPTOSOMAL PREPARATIONS BY TETRAHYDROISOQUINOLINE AND TETRAHYDROPROTOBERBERINE ALKALOIDS [J].