FROM WHITE SPOTS TO STEM-CELLS - THE ROLE OF THE KIT RECEPTOR IN MAMMALIAN DEVELOPMENT

被引：165
作者：
FLEISCHMAN, RA [1 ]
机构：
[1] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DALLAS,TX 75235
来源：
TRENDS IN GENETICS | 1993年 / 9卷 / 08期
关键词：
D O I：
10.1016/0168-9525(93)90015-A
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.
引用
收藏
页码：285 / 290
页数：6
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