NASAL ADMINISTRATION OF RETINAL ANTIGENS SUPPRESSES THE INFLAMMATORY RESPONSE IN EXPERIMENTAL ALLERGIC UVEORETINITIS - A PRELIMINARY-REPORT OF INTRANASAL INDUCTION OF TOLERANCE WITH RETINAL ANTIGENS

被引：91

作者：

DICK, AD ^{[1
]}

CHENG, YF ^{[1
]}

MCKINNON, A ^{[1
]}

LIVERSIDGE, J ^{[1
]}

FORRESTER, JV ^{[1
]}

机构：

[1] UNIV ABERDEEN SCH MED,DEPT PATHOL,ABERDEEN AB9 2ZD,SCOTLAND

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 1993年 / 77卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1136/bjo.77.3.171

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Current immunotherapy of posterior uveitis is non-specific and limited by drug toxicity and unpredictable relapses on therapy. Alternative modes of therapy being investigated using the rat model of experimental autoimmune uveoretinitis (EAU) have included the induction of tolerance with oral administration of milligram quantities of retinal antigens. In this preliminary report we demonstrate that tolerance to retinal antigens can be induced via the upper respiratory tract with microgram doses of antigen, preventing subsequent induction of EAU.

引用

页码：171 / 175

页数：5

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