Therapeutic drug monitoring in inflammatory bowel disease

被引：6

作者：

Kopylov, Uri ^{[1
,2
,3
]}

Ben-Horin, Shomron ^{[2
,3
]}

Seidman, Ernest ^{[1
]}

机构：

[1] McGill Univ, Hlth Ctr, Div Gastroenterol, 1650 Cedar Ave, Montreal, PQ H3G 1A4, Canada

[2] Tel Aviv Univ, Sheba Med Ctr, Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel

来源：

ANNALS OF GASTROENTEROLOGY | 2014年 / 27卷 / 04期

关键词：

Inflammatory bowel disease; Crohn's disease; ulcerative colitis; biologics; thiopurines;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Tumor necrosis factor (TNF)-alpha inhibitors and thiopurines are among the most important classes of medications utilized in the clinical management of Crohn's disease and ulcerative colitis. A significant proportion of patients loses response to these agents or develops adverse effects during the course of the treatment. Monitoring of drug levels and anti-drug antibodies (for TNF-alpha inhibitors) and metabolite levels (for thiopurines) can provide valuable insight into the possible etiology of unfavorable outcomes and allow for an appropriate management strategy for these patients. This review summarizes the current knowledge on the clinical implications of therapeutic drug monitoring in inflammatory bowel disease patients treated with TNF-alpha inhibitors and thiopurines.

引用

收藏

页码：304 / 312

页数：9

相关论文

共 87 条

[11] Addition of an Immunomodulator to Infliximab Therapy Eliminates Antidrug Antibodies in Serum and Restores Clinical Response of Patients With Inflammatory Bowel Disease [J].

Ben-Horin, Shomron ;

Waterman, Matti ;

Kopylov, Uri ;

Yavzori, Miri ;

Picard, Orit ;

Fudim, Ella ;

Awadie, Halim ;

Weiss, Batia ;

Chowers, Yehuda .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2013, 11 (04) :444-447

[12] The immunogenic part of infliximab is the F(ab′)2, but measuring antibodies to the intact infliximab molecule is more clinically useful [J].

Ben-Horin, Shomron ;

Yavzori, Miri ;

Katz, Lior ;

Kopylov, Uri ;

Picard, Orit ;

Fudim, Ella ;

Coscas, Daniel ;

Bar-Meir, Simon ;

Goldstein, Itamar ;

Chowers, Yehuda .

GUT, 2011, 60 (01) :41-48

[13] Loss of Response and Need for Adalimumab Dose Intensification in Crohn's Disease: A Systematic Review [J].

Billioud, Vincent ;

Sandborn, William J. ;

Peyrin-Biroulet, Laurent .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2011, 106 (04) :674-684

[14] Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease [J].

Bradford, Kara ;

Shih, David Q. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2011, 17 (37) :4166-4173

[15]

Brandse JF, 2013, GASTROENTEROLOGY, V144, pS36

[16] Detection of infliximab levels and anti-infliximab antibodies: a comparison of three different assays [J].

Casteele, N. Vande ;

Buurman, D. J. ;

Sturkenboom, M. G. G. ;

Kleibeuker, J. H. ;

Vermeire, S. ;

Rispens, T. ;

van der Kleij, D. ;

Gils, A. ;

Dijkstra, G. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2012, 36 (08) :765-771

[17] Dose optimization is effective in ulcerative colitis patients losing response to infliximab: A collaborative multicentre retrospective study [J].

Cesarini, Monica ;

Katsanos, Konstantinos ;

Papamichael, Konstantinos ;

Ellul, Pierre ;

Lakatos, Peter L. ;

Caprioli, Flavio ;

Kopylov, Uri ;

Tsianos, Epameinondas ;

Mantzaris, Gerassimos J. ;

Ben-Horin, Shomron ;

Danese, Silvio ;

Fiorino, Gionata .

DIGESTIVE AND LIVER DISEASE, 2014, 46 (02) :135-139

[18] The Role of Thiopurines in Reducing the Need for Surgical Resection in Crohn's Disease: A Systematic Review and Meta-Analysis [J].

Chatu, Sukhdev ;

Subramanian, Venkataraman ;

Saxena, Sonia ;

Pollok, Richard C. G. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (01) :23-35

[19] Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease [J].

Chouchana, L. ;

Narjoz, C. ;

Beaune, P. ;

Loriot, M-A ;

Roblin, X. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2012, 35 (01) :15-36

[20] The relationship of serum infliximab concentrations to clinical improvement in rheumatoid arthritis - Results from ATTRACT, a multicenter, randomized, double-blind, placebo-controlled trial [J].

Clair, EWS ;

Wagner, CL ;

Fasanmade, AA ;

Wang, B ;

Schaible, T ;

Kavanaugh, A ;

Keystone, EC .

ARTHRITIS AND RHEUMATISM, 2002, 46 (06) :1451-1459

← 1 2 3 4 5 6 7 8 9 →