UP-REGULATION OF INTERLEUKIN (IL)-6 RECEPTOR GENE-EXPRESSION INVITRO AND INVIVO IN IL-6 DEPRIVED MYELOMA CELLS

被引：18
作者：
PORTIER, M
LEES, D
CARON, E
JOURDAN, M
BOIRON, JM
BATAILLE, R
KLEIN, B
机构：
[1] INSERM,U291,99 RUE PUECH VILLA,F-34090 MONTPELLIER,FRANCE
[2] HOP ST ELOI,CTR GUI DE CHAULIAC,CONSULTAT IMMUNORHUMATOL,F-34059 MONTPELLIER,FRANCE
来源：
FEBS LETTERS | 1992年 / 302卷 / 01期
关键词：
IL-6; RECEPTOR; MULTIPLE MYELOMA;
D O I：
10.1016/0014-5793(92)80278-O
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Myeloma cells absolutely require interleukin-6 (IL-6) for growing in vivo in patients with multiple myeloma and exogenous IL-6-dependent myeloma cell lines have been reproducibly obtained. In this study we show a dramatic up-regulation of the IL-6 receptor (gp80 chain) gene expression in myeloma cell lines following the removal of exogenous IL-6. Such a regulation was also known to occur in IL-6-deprived myeloma cells in vivo in three patients who were treated with optimal doses of anti-IL-6 monoclonal antibodies. The direct effect of IL-6 on IL-6 receptor gene expression in myeloma cells was further confirmed by adding IL-6 to an autonomously growing myeloma cell line.
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收藏
页码：35 / 38
页数：4
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