DEVELOPMENT OF THYROID-DISEASE DURING THERAPY OF CHRONIC VIRAL-HEPATITIS WITH INTERFERON ALFA

被引：224

作者：

LISKERMELMAN, M

DIBISCEGLIE, AM

USALA, SJ

WEINTRAUB, B

MURRAY, LM

HOOFNAGLE, JH

机构：

[1] NIDDKD,DIGEST DIS BRANCH,LIVER DIS SECT,BLDG 10,ROOM 4D 52,BETHESDA,MD 20892

[2] NIDDKD,MOLEC CELLULAR & NUTR ENDOCRINOL,BETHESDA,MD 20892

来源：

GASTROENTEROLOGY | 1992年 / 102卷 / 06期

关键词：

D O I：

10.1016/0016-5085(92)90348-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Six of 237 (2.5%) patients with chronic viral hepatitis who were treated with recombinant interferon alfa developed thyroid disease while on treatment. Three patients developed hyperthyroidism, two of whom developed detectable levels of thyroid-stimulating immunoglobulin; three patients developed hypothyroidism in association with high titers of antithyroglobulin and/or antimicrosomal antibodies. The thyroid disease did not remit when interferon therapy was stopped, and all six patients required definitive therapy for the thyroid disease. These findings suggest that a small proportion of patients treated with interferon alfa develop autoimmune reactions and can develop autoimmune thyroid disease. © 1992.

引用

页码：2155 / 2160

页数：6

共 19 条

[1] HYPOTHYROIDISM AFTER TREATMENT WITH INTERLEUKIN-2 AND LYMPHOKINE-ACTIVATED KILLER CELLS [J].