CORRELATION BETWEEN CHEMICAL-STRUCTURE AND ANTIARRHYTHMIC EFFECT OF ETHACIZINE AND ITS ANALOGS

被引：0

作者：

TURILOVA, AI ^{[1
]}

BERDYAYEV, SY ^{[1
]}

GRITSENKO, AN ^{[1
]}

SENOVA, ZP ^{[1
]}

机构：

[1] ACAD MED SCI USSR,INST PHARMACOL,BLOOD CIRCULAT PHARMACOL LAB,MOSCOW 125315,USSR

来源：

FARMAKOLOGIYA I TOKSIKOLOGIYA | 1990年 / 53卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The relationship between the chemical structure and the antiarhythmic activity of phenothiazine derivatives - ethacizine and its analogues - was estimated quantitatively by the value of the antiarrhytmic effect on aconitine model in consious rats. The lengthening of the side chain of nitrogen atom in position 10 of phenothiazine cycle by one methylene group as well as the substitution of demethylamine radical for diethylamine one increased the antiarrhytmic activity; the toxicity of the compound being also increased. Ethacizine was found to possess the highest antiarrhytmic activity and the greatest antiarrhythmic index.

引用

页码：20 / 21

页数：2