IN-SITU ATR FTIR STUDIES OF PROTEIN ADSORPTION ON POLYMERIC MATERIALS - EFFECTIVENESS OF SURFACE HEPARINIZATION

被引：10

作者：

MAGNANI, A ^{[1
]}

BUSI, E ^{[1
]}

BARBUCCI, R ^{[1
]}

机构：

[1] UNIV SIENA,DIPARTIMENTO CHIM,I-53100 SIENA,ITALY

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 1994年 / 5卷 / 12期

关键词：

D O I：

10.1007/BF01172021

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The adsorption of two proteins from human plasma (human serum albumin (HSA) and human fibrinogen (HFG) onto six different polymeric surfaces (two of which are heparinized), has been studied by in situ ATR/FTIR spectroscopy. The different surface characteristics ar e reflected by different interfacial behaviours of the two proteins, but while both proteins unfold upon adsorption on all the different non-heparinized materials, they maintain the native conformation once adsorbed on the heparinized surfaces. These findings emphasize the effectiveness of surface heparinization.

引用

页码：839 / 843

页数：5

共 21 条

[1] IN-VITRO BIOCOMPATIBILITY EVALUATION OF A HEPARINIZABLE MATERIAL (PUPA), BASED ON POLYURETHANE AND POLY(AMIDO-AMINE) COMPONENTS [J].