PROTECTIVE EFFECT OF LOW-DOSES OF AN ANTI-IL-4 MONOCLONAL-ANTIBODY IN A MURINE MODEL OF ACUTE TOXOPLASMOSIS

被引：21

作者：

VILLARD, O

CANDOLFI, E

DESPRINGRE, JL

DEROUIN, F

MARCELLIN, L

VIVILLE, S

KIEN, T

机构：

[1] FAC MED STRASBOURG,INST PARASITOL & MED TROP,F-67000 STRASBOURG,FRANCE

[2] HOP ST LOUIS,PARASITOL MYCOL LAB,F-75475 PARIS,FRANCE

[3] HOP UNIV STRASBOURG,SERV ANATOMOPATHOL,F-67098 STRASBOURG,FRANCE

[4] WELLCOME CRC INST,CAMBRIDGE CB2 1QR,ENGLAND

来源：

PARASITE IMMUNOLOGY | 1995年 / 17卷 / 05期

基金：

英国惠康基金;

关键词：

TOXOPLASMA GONDII; MURINE TOXOPLASMOSIS; INTERLEUKIN-4;

D O I：

10.1111/j.1365-3024.1995.tb01020.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Treatment with an anti-IL-4 monoclonal antibody protected susceptible C57BL/6 mice against challenge with an avirulent strain of T. gondii. Antibody therapy with 100 mu g on days 0 and 7 post infection resulted in 100% survival of C57/BL6 mice infected orally. Survival was dose-dependent. Treatment prolonged parasitaemia but did not alter tissue parasite load. Increased serum IgG2a and IFN-gamma levels, together with low levels of lgG1, in mice treated with anti-IL-4 or an isotype control, indicated a trend towards a predominant Th1 response in all survivors. The persistence of an IgE response after treatment suggests that endogenous IL-4 was only partly neutralized or that other factors can induce the production of IgE in murine toxoplasmosis.

引用

页码：233 / 236

页数：4

共 13 条

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