EFFECT OF KAINIC ACID-INDUCED STATUS EPILEPTICUS ON INOSITOL-TRISPHOSPHATE AND SEIZURE-INDUCED BRAIN-DAMAGE IN MATURE AND IMMATURE ANIMALS

被引：18
|
作者：
CARMANT, L [1 ]
LIU, Z [1 ]
WERNER, SJ [1 ]
MIKATI, MA [1 ]
HOLMES, GL [1 ]
机构：
[1] HARVARD UNIV, CHILDRENS HOSP, SCH MED, DEPT NEUROL, BOSTON, MA 02115 USA
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1995年 / 89卷 / 01期
关键词：
KAINIC ACID; STATUS EPILEPTICUS; INOSITOL-TRISPHOSPHATE; SEIZURE-INDUCED BRAIN DAMAGE; EXCITATORY AMINO ACID;
D O I：
10.1016/0165-3806(95)00110-Y
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We investigated the role of excitatory amino acids in the activation of the phosphoinositide pathway during kainic acid-induced seizures in mature and immature animals. Kainic acid caused more severe seizures in the immature animals, but no hippocampal damage or induction of phosphoinositide hydrolysis. In mature animals, seizures were mild but severe hippocampal damage was seen and was associated with a marked and sustained release of inositol-trisphosphate, suggesting a role of this pathway and intracellular calcium stores in seizure-induced brain damage.
引用
收藏
页码：67 / 72
页数：6
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