SYNTHESIS OF [S-35] 3H-1,2-BENZODITHIOLE-3-ONE-1,1-DIOXIDE - APPLICATION IN THE PREPARATION OF SITE-SPECIFICALLY S-35 LABELED OLIGONUCLEOTIDES

被引：7
作者：
IYER, RP
TAN, WT
YU, D
AGRAWAL, S
机构：
[1] Hybridon Inc., Worcester, MA 01605, One Innovation Drive
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 51期
关键词：
D O I：
10.1016/0040-4039(94)88501-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of [S-35]3H-1,2-benzodithiole-3-one-1,1-dioxide (1) and its use in the perparation of site-specifically S-35-labeled oligonucleotides is illustrated.
引用
收藏
页码：9521 / 9524
页数：4
相关论文
共 11 条
  • [1] PHARMACOKINETICS, BIODISTRIBUTION, AND STABILITY OF OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES IN MICE
    AGRAWAL, S
    TEMSAMANI, J
    TANG, JY
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) : 7595 - 7599
  • [2] ANDRAD M, 1994, BIOORG MED CHEM LETT, P2017
  • [3] ADVANCES IN THE SYNTHESIS OF OLIGONUCLEOTIDES BY THE PHOSPHORAMIDITE APPROACH
    BEAUCAGE, SL
    IYER, RP
    [J]. TETRAHEDRON, 1992, 48 (12) : 2223 - 2311
  • [4] DEOXYNUCLEOSIDE PHOSPHORAMIDITES - A NEW CLASS OF KEY INTERMEDIATES FOR DEOXYPOLYNUCLEOTIDE SYNTHESIS
    BEAUCAGE, SL
    CARUTHERS, MH
    [J]. TETRAHEDRON LETTERS, 1981, 22 (20) : 1859 - 1862
  • [5] GAREGG PJ, 1985, CHEM SCRIPTA, V25, P280
  • [6] THE AUTOMATED SYNTHESIS OF SULFUR-CONTAINING OLIGODEOXYRIBONUCLEOTIDES USING 3H-1,2-BENZODITHIOL-3-ONE 1,1-DIOXIDE AS A SULFUR-TRANSFER REAGENT
    IYER, RP
    PHILLIPS, LR
    EGAN, W
    REGAN, JB
    BEAUCAGE, SL
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (15) : 4693 - 4699
  • [7] 3H-1,2-BENZODITHIOLE-3-ONE 1,1-DIOXIDE AS AN IMPROVED SULFURIZING REAGENT IN THE SOLID-PHASE SYNTHESIS OF OLIGODEOXYRIBONUCLEOSIDE PHOSPHOROTHIOATES
    IYER, RP
    EGAN, W
    REGAN, JB
    BEAUCAGE, SL
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (03) : 1253 - 1254
  • [8] REACTION OF ACETYL ARALKYL DISULFIDES WITH TRIPHENYLPHOSPHINE
    KAWAMURA, S
    SATO, A
    NAKABAYASHI, T
    HAMADA, M
    [J]. CHEMISTRY LETTERS, 1975, (12) : 1231 - 1234
  • [9] MCKIBBEN M, 1923, J CHEM SOC, P170
  • [10] LARGE-SCALE SYNTHESIS, PURIFICATION, AND ANALYSIS OF OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES
    PADMAPRIYA, AA
    TANG, JY
    AGRAWAL, S
    [J]. ANTISENSE RESEARCH AND DEVELOPMENT, 1994, 4 (03): : 185 - 199
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