LOCALIZATION OF THE GENE FOR THE CILIARY NEUROTROPHIC FACTOR-RECEPTOR (CNTFR) TO HUMAN CHROMOSOME-9

被引：8

作者：

DONALDSON, DH

BRITT, DE

JONES, C

JACKSON, CL

PATTERSON, D

机构：

[1] ELEANOR ROOSEVELT INST,1899 GAYLORD ST,DENVER,CO 80206

[2] UNIV COLORADO,HLTH SCI CTR,DENVER,CO 80262

[3] RHODE ISL HOSP,DEPT PATHOL,PROVIDENCE,RI 02902

[4] BROWN UNIV,PROVIDENCE,RI 02912

来源：

GENOMICS | 1993年 / 17卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1409

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ciliary neurotrophic factor (CNTF) has recently been found to be important for the survival of motor neurons and has shown activity in animal models of amyotrophic lateral sclerosis (ALS). CNTF therefore holds promise as a trearment for ALS, and it and its receptor (CNTFR) are candidates for a gene involved in familial ALS. The CNTFR gene was mapped to chromosome 9 by PCR on a pnnel of human/CHO somatic cell hybrids and localized to 9p13 by PCR on a panel of radiation hybrids. © 1993 Academic Press. All rights reserved.

引用

页码：782 / 784

页数：3

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