Microscopic polyangiitis secondary to silica exposure

被引：6

作者：

Vega Miranda, Juliana ^{[1
]}

Pinto Penaranda, Luis Fernando ^{[2
]}

Marquez Hernandez, Javier Dario ^{[2
]}

Velasquez Franco, Carlos Jaime ^{[2
,3
]}

机构：

[1] Univ Pontificia Bolivariana, Med Interna, Medellin, Colombia

[2] Hosp Pablo Tobon Uribe, Grupo Reumatol, Medellin, Colombia

[3] Univ Pontificia Bolivariana, Fac Med Escuela Ciencias Salud, Medellin, Colombia

来源：

REUMATOLOGIA CLINICA | 2014年 / 10卷 / 03期

关键词：

Silicosis; Microscopic polyangiitis; Antibodies antineutrophil cytoplasmic; Rapidly progressive glomerulonephritis; with pulmonary hemorrhage; Autoimmunity;

D O I：

10.1016/j.reuma.2013.04.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is sufficient evidence of the capqcity of silica to induce autoimmunity in patients with some type of genetic susceptibility. There are several autoimmune diseases related to this exposure (rheumatoid arthritis, Sjogren's syndrome, sarcoidosis, systemic sclerosis). Nodular silicosis (clinical expression of this exposure in lungs) generates apoptosis, inflammation, loss of tolerance and a respiratory burst. There is evidence that relates silica with induction of antineutrophil cytoplasmic antibodies, but, until it is better explained, the reports of systemic vasculitis secondary to silica exposure are inconclusive. We describe a case of a patient with a history of occupational exposure to silica who developed microscopic polyangiitis. (C) 2013 Elsevier Espafia, S.L. All rights reserved.

引用

页码：180 / 182

页数：3

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