COSEGREGATION OF BLOOD-PRESSURE WITH ANGIOTENSIN CONVERTING ENZYME AND ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR GENES USING DAHL SALT-SENSITIVE RATS

被引：164
作者：
DENG, YL
RAPP, JP
机构：
[1] MED COLL OHIO, DEPT MED, TOLEDO, OH 43699 USA
[2] MED COLL OHIO, DEPT PATHOL, TOLEDO, OH 43699 USA
来源：
NATURE GENETICS | 1992年 / 1卷 / 04期
关键词：
D O I：
10.1038/ng0792-267
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We have evaluated the genes for angiotensin converting enzyme (ACE) and guanylyl cyclase A/atrial natriuretic peptide receptor (GCA) for genetic effects on blood pressure response to high salt diet. In F2 rats derived from Milan normotensive and Dahl salt-hypertension sensitive (S) rats, both ACE and GCA cosegregated with blood pressure, and rats that were homozygous for the S allele at both the ACE and GCA loci had inordinately high blood pressure. In F2 derived from Wistar Kyoto (WKY) and S rats, GCA revealed positive cosegregation with blood pressure, but ACE did not. We conclude that certain alleles at the GCA and ACE loci (or at loci closely linked to them) have a significant genetic impact on blood pressure response to high salt in specific rat strains.
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页码：267 / 272
页数：6
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