A SELECTIVE AND SENSITIVE KINETIC METHOD FOR THE DETERMINATION OF PROCAINE AND BENZOCAINE IN PHARMACEUTICALS

被引：8

作者：

CARMONA, M ^{[1
]}

SILVA, M ^{[1
]}

PEREZBENDITO, D ^{[1
]}

机构：

[1] UNIV CORDOBA,FAC SCI,DEPT ANALYT CHEM,E-14004 CORDOBA,SPAIN

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 2-3期

关键词：

PROCAINE; BENZOCAINE; PHARMACEUTICALS; STOPPED-FLOW; SPECTROPHOTOMETRY;

D O I：

10.1016/0731-7085(92)80022-F

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple stopped-flow method for the determination of procaine and benzocaine which is suitable for their routine analysis in pharmaceutical samples is reported. The method is based on a condensation reaction between each compound and 4-dimethylaminocinnamaldehyde, which yields coloured compounds and which are monitored spectrophotometrically. The calibration graph generated is linear over the range 0.5-20-mu-g ml-1 (RSD 0.73%) for procaine and 0.5-15-mu-g ml-1 (RSD 0.40%) for benzocaine, and the selectivity is very high in both cases. The proposed methods were satisfactorily applied to the determination of the two drugs in various pharmaceutical samples. A procedure for resolution of procaine-benzocaine mixtures in mass ratios between 15:1 and 1:7 with a precision of ca 1% was developed in order to determine one compound in the presence of the other with no interference.

引用

页码：145 / 152

页数：8

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