TRANSCRIPTIONAL CONTROL BY PROTEIN-PHOSPHORYLATION - SIGNAL TRANSMISSION FROM THE CELL-SURFACE TO THE NUCLEUS

被引：656
作者：
KARIN, M [1 ]
HUNTER, T [1 ]
机构：
[1] SALK INST BIOL STUDIES,MOLEC BIOL & VIROL LAB,LA JOLLA,CA 92037
来源：
CURRENT BIOLOGY | 1995年 / 5卷 / 07期
关键词：
D O I：
10.1016/S0960-9822(95)00151-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two general mechanisms have evolved for the rapid and accurate transmission of signals from cell-surface receptors to the nucleus, both involving protein phosphorylation. One mechanism depends on the regulated translocation of activated protein kinases from the cytoplasm to the nucleus, where they phosphorylate target transcription factors, In the second mechanism, transcription factors are kept in a latent state in the cytoplasm and are translocated into the nucleus upon activation.
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页码：747 / 757
页数：11
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