TRANSCRIPTIONAL CONTROL BY PROTEIN-PHOSPHORYLATION - SIGNAL TRANSMISSION FROM THE CELL-SURFACE TO THE NUCLEUS

被引：656
作者：
KARIN, M [1 ]
HUNTER, T [1 ]
机构：
[1] SALK INST BIOL STUDIES,MOLEC BIOL & VIROL LAB,LA JOLLA,CA 92037
来源：
CURRENT BIOLOGY | 1995年 / 5卷 / 07期
关键词：
D O I：
10.1016/S0960-9822(95)00151-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two general mechanisms have evolved for the rapid and accurate transmission of signals from cell-surface receptors to the nucleus, both involving protein phosphorylation. One mechanism depends on the regulated translocation of activated protein kinases from the cytoplasm to the nucleus, where they phosphorylate target transcription factors, In the second mechanism, transcription factors are kept in a latent state in the cytoplasm and are translocated into the nucleus upon activation.
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页码：747 / 757
页数：11
相关论文
共 102 条
[1]  
ADLER V, 1994, J BIOL CHEM, V269, P11186
[2]  
ADLER V, 1992, J BIOL CHEM, V267, P17001
[3]   PHORBOL ESTERS STIMULATE THE PHOSPHORYLATION OF C-JUN BUT NOT V-JUN - REGULATION BY THE N-TERMINAL DELTA DOMAIN [J].
ADLER, V ;
FRANKLIN, CC ;
KRAFT, AS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5341-5345
[4]  
Ahn Natalie G., 1992, Current Opinion in Cell Biology, V4, P992, DOI 10.1016/0955-0674(92)90131-U
[5]  
ALVAREZ E, 1991, J BIOL CHEM, V266, P15277
[6]   SEX, STRESS AND INTEGRITY - THE IMPORTANCE OF MAP KINASES IN YEAST [J].
AMMERER, G .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1994, 4 (01) :90-95
[7]   THE ROLE OF JUN, FOS AND THE AP-1 COMPLEX IN CELL-PROLIFERATION AND TRANSFORMATION [J].
ANGEL, P ;
KARIN, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1072 (2-3) :129-157
[8]   A FAMILY OF TRANSCRIPTIONAL ADAPTER PROTEINS TARGETED BY THE E1A ONCOPROTEIN [J].
ARANY, Z ;
NEWSOME, D ;
OLDREAD, E ;
LIVINGSTON, DM ;
ECKNER, R .
NATURE, 1995, 374 (6517) :81-84
[9]   E1A-ASSOCIATED P300 AND CREB-ASSOCIATED CBP BELONG TO A CONSERVED FAMILY OF COACTIVATORS [J].
ARANY, Z ;
SELLERS, WR ;
LIVINGSTON, DM ;
ECKNER, R .
CELL, 1994, 77 (06) :799-800
[10]   ACTIVATION OF CAMP AND MITOGEN RESPONSIVE GENES RELIES ON A COMMON NUCLEAR FACTOR [J].
ARIAS, J ;
ALBERTS, AS ;
BRINDLE, P ;
CLARET, FX ;
SMEAL, T ;
KARIN, M ;
FERAMISCO, J ;
MONTMINY, M .
NATURE, 1994, 370 (6486) :226-229
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