IMMUNOHISTOCHEMICAL ANALYSIS OF THE MUCOSAL LESION IN MUCOCUTANEOUS LEISHMANIASIS

被引：3
作者：
ESTERRE, P
GUERRET, S
RAVISSE, P
DIMIERDAVID, L
DEDET, JP
GRIMAUD, JA
机构：
[1] INST PASTEUR MADAGASCAR, IMMUNOL UNIT, ANTANANARIVO, MADAGASCAR
[2] INST PASTEUR, CNRS, URA 1459, MOLEC & CELLULAR PATHOL UNIT TISSUE FIBROSIS, F-69365 LYON 07, FRANCE
[3] INST PASTEUR, HISTOPATHOL UNIT, F-75235 PARIS 15, FRANCE
[4] INST BOLIVIANO BIOL ALTURA, PARASITOL LAB, LA PAZ, BOLIVIA
来源：
PARASITE | 1994年 / 1卷 / 04期
关键词：
IMMUNOLOGY; IMMUNOPATHOLOGY; PATHOLOGY; MUCOCUTANEOUS LEISHMANIASIS; LEISHMANIA BRAZILIENSIS;
D O I：
10.1051/parasite/1994014305
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Using antibodies against surface antigens of inflammatory cells and against extra-cellular matrix components, immunocytochemical studies permit the investigation of the in situ cellular immune response and the associated fibrosis, in mucosal lesions. 57 paraffin embedded skin biopsies of mucocutaneous leishmaniasis originating from Bolivia, and clue to Leishmania (Viannia) braziliensis, were studied. Memory T cells predominate within a non-organized granulomatous reaction, in which were observed proliferating macrophages. At the top of the lesion, epithelial cells expressed HLA-DR. Some characteristics of this lesion, particularly its chronic destructive pattern, presently lack any clear explanation.
引用
收藏
页码：305 / 309
页数：5
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