DECREASED NATURAL-KILLER (NK) CELL-ACTIVITY IN ZINC-DEFICIENT RATS

被引：15
|
作者：
OZTURK, G
ERBAS, D
IMIR, T
BOR, NM
机构：
[1] GAZI UNIV,FAC MED,DEPT PHYSIOL,BESEVLER 06510,TURKEY
[2] GAZI UNIV,FAC MED,DEPT MICROBIOL,BESEVLER 06510,TURKEY
[3] HACETTEPE UNIV,FAC MED,MED & SURG RES CTR,ANKARA 06100,TURKEY
来源：
GENERAL PHARMACOLOGY | 1994年 / 25卷 / 07期
关键词：
ZINC; NATURAL KILLER; LIPOPOLYSACCHARIDE; PLASMA ZINC; ZINC DEFICIENCY;
D O I：
10.1016/0306-3623(94)90180-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. In the study, the effect of zinc deficiency, a natural killer (NK), and lipopolysaccharide (LPS) activated NK cell activity were investigated. 2. Rats were fed with zinc-deficient and normal diet for 3 weeks. 3. NK and LPS activated NK cell activity was 7.2 +/- 1.8%/10(6) cells (n = 10) and 9.5 +/- 4.3%/10(6) cells (n = 10), respectively, in the zinc deficient group. In the control group fed with normal diet, NK and LPS activated NK cell activity was 22.2 +/- 3.3%/10(6) cells (n = 10) and 32.5 +/- 3.5%/10(6) cells (n = 10), respectively. 4. Plasma zinc concentration was 131.7 +/- 8.8 mu g/dl in the zinc-deficient group and 206 +/- 17.7 mu g/dl in the control group. 5. The results suggest that decreased NK and LPS activated NK cell activity is associated with zinc deficiency.
引用
收藏
页码：1499 / 1503
页数：5
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