RIFAMPICINE TREATMENT OF PRIMARY BILIARY-CIRRHOSIS

被引：0
|
作者：
LOGINOV, AS
RESHETNYAK, VI
PETRAKOV, AV
机构：
来源：
TERAPEVTICHESKII ARKHIV | 1993年 / 65卷 / 08期
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中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Seven patients with primary biliary cirrhosis were treated with rifampicine administered for 2 weeks in a daily dose 450-600 mg. Due to the treatment the itch disappeared completely in 4 and decreased significantly in 3 patients. As shown by the antipyrine test, half-life and clearance of antipyrine returned to normal suggesting cytochrome P-450 induction as a result of hydroxylation activity. There was a tendency to lowering of bilirubine, cholesterol, alkaline phosphatase, asparagine - and alanine aminotransferase against an increase in gamma-globulines. The differences were, however, insignificant. Rifampicine tolerance was satisfactory.
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页码：57 / 62
页数：6
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