ANTIVIRAL SYNERGY BETWEEN INHIBITORS OF HIV PROTEINASE AND REVERSE-TRANSCRIPTASE

被引:25
|
作者
CRAIG, JC
DUNCAN, IB
WHITTAKER, L
ROBERTS, NA
机构
[1] Department of Biology, Roche Products Limited, Welwyn Garden City, Herts AL7 3AY
来源
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1993年 / 4卷 / 03期
关键词
D O I
10.1177/095632029300400305
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ro 31-8959, a potent and specific inhibitor of HIV proteinases, is shown to interact synergistically in combination with nucleoside analogue inhibitors of HIV reverse transcriptase (AZT, ddC, 2'-FddC). Ninety per cent inhibition endpoints (IC90), obtained from checkerboard titrations of compound mixtures on CEM-T4 cells infected with HIV-1 strain GB8, have been further analysed. Compared with concentrations needed when inhibitors are used individually, reductions of between 2- and 30-fold were observed in combination, depending on the nucleoside analogue and the ratio of concentrations employed. The results suggest that combinations of AZT or ddC with Ro 31-8959 should be considered for development as candidate antiviral treatments of patients with HIV infection.
引用
收藏
页码:161 / 166
页数:6
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