EFFECTS OF THROMBOXANE SYNTHETASE INHIBITOR (OKY-046) ON PLACENTAL BLOOD-FLOW, PLACENTAL WEIGHT AND FETAL WEIGHT IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

被引：2
作者：
FURUHASHI, N
TSUJIEI, M
KIMURA, H
NAGAE, H
YAJIMA, A
机构：
[1] Department of Obstetrics and Gynecology, Tohoku University, School of Medicine, Sendai
来源：
GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1993年 / 35卷 / 01期
关键词：
THROMBOXANE SYNTHETASE INHIBITOR (OKY-046); PLACENTAL BLOOD FLOW; PLACENTAL WEIGHT; FETAL WEIGHT; SPONTANEOUSLY HYPERTENSIVE RAT;
D O I：
10.1159/000292657
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Recently, thromboxane synthetase inhibitor has been used for the treatment of preeclampsia. In this study, we investigated the effects of thromboxane synthetase inhibitor (OKY-046) on placental blood flow (measured with clearance of hydrogen gas generated by electrolysis) in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The systolic blood pressure of OKY-046-treated SHR (1, 4 and 8 mg/kg) decreased significantly (p < 0.05); however, the systolic blood pressure of WKY did not decrease. The placental blood flow of both OKY-046-treated WKY and SHR did not decrease. We found that OKY-046 has no reducing effect on placental blood flow in rats, and systolic blood pressure of SHR decreases. These data suggest that thromboxane synthetase inhibitor might have a beneficial effect on pre-eclampsia.
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收藏
页码：23 / 26
页数：4
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