RELATION OF CATHEPSIN-D LEVEL TO THE ESTROGEN-RECEPTOR IN HUMAN BREAST-CANCER

被引:17
|
作者
MARSIGLIANTE, S [1 ]
BISCOZZO, L [1 ]
GRECO, S [1 ]
LEO, G [1 ]
STORELLI, C [1 ]
机构
[1] OSPED MULTIZONALE V FAZZI,ANAL CLIN LAB,LECCE,ITALY
来源
INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH | 1992年 / 22卷 / 01期
关键词
CATHEPSIN-D; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; P-29; BREAST CANCER;
D O I
10.1007/BF02591395
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Seventy-three primary human breast cancers were analyzed to assess the presence of estrogen and progesterone receptors, the p29 protein, and the total cathepsin D status. No significant relationship was found between cathepsin D concentration and the presence of ER or PR, either by Fisher's exact test or Spearman's rank correlation (P > 0.1). However, a significant association was found between cathepsin D and p29 (Fisher's exact test, P < 0.001) and between cathepsin D and steroid receptor status in samples expressing both estrogen and progesterone receptors (positive by steroid binding assay and enzyme immunoassay) (P < 0.05). This association was more significant in tissues expressing estrogen and progesterone receptors as well as p29 (P < 0.001). In contrast, cathepsin D synthesis was not related to tumor size, lymph node involvement, or patient's age (P > 0.05). Steroid receptors and cathepsin D were also assayed in samples of non-malignant tissue from 16 mastectomies; there was a significantly higher relative concentration of cathepsin D in the malignant specimens (Student's t-test, P < 0.001).
引用
收藏
页码:52 / 57
页数:6
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