A CYTOTOXIC PRINCIPLE OF THE BROWN ALGA SARGASSUM-TORTILE AND STRUCTURES OF CHROMENES

被引：58

作者：

NUMATA, A

KANBARA, S

TAKAHASHI, C

FUJIKI, R

YONEDA, M

USAMI, Y

FUJITA, E

机构：

[1] Osaka University of Pharmaceutical Sciences, Matsubara, Osaka, 580

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 04期

关键词：

SARGASSUM-TORTILE; SARGASSACEAE; WHOLE SEAWEED; CYTOTOXICITY; BENZOQUINONES; CHROMENES;

D O I：

10.1016/0031-9422(92)80262-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioassay-directed fractionation of a methanolic extract of the marine alga Sargassum tortile has led to the isolation and characterization of eight compounds which include the new chromenes sargaol, sargasal-II, and sargadiols-I and -II in addition to sargasal-I, hydroxysargaquinone, kjellmanianone, and fucosterol. Among them, hydroxysargaquinone and sargasals-I and -II demonstrated significant and marginal cytotoxicity against cultured P-388 lymphocytic leukemia cells, respectively.

引用

页码：1209 / 1213

页数：5

共 10 条

[1] SYNTHESIS AND STEREOCHEMICAL ASSIGNMENT OF CIS-AND TRANS-2-METHYL-2-PENTENOIC ACID AND CORRESPONDING ESTERS,ALDEHYDES,AND ALCOHOLS [J].