A CYTOTOXIC PRINCIPLE OF THE BROWN ALGA SARGASSUM-TORTILE AND STRUCTURES OF CHROMENES

被引：58
作者：
NUMATA, A
KANBARA, S
TAKAHASHI, C
FUJIKI, R
YONEDA, M
USAMI, Y
FUJITA, E
机构：
[1] Osaka University of Pharmaceutical Sciences, Matsubara, Osaka, 580
来源：
PHYTOCHEMISTRY | 1992年 / 31卷 / 04期
关键词：
SARGASSUM-TORTILE; SARGASSACEAE; WHOLE SEAWEED; CYTOTOXICITY; BENZOQUINONES; CHROMENES;
D O I：
10.1016/0031-9422(92)80262-D
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioassay-directed fractionation of a methanolic extract of the marine alga Sargassum tortile has led to the isolation and characterization of eight compounds which include the new chromenes sargaol, sargasal-II, and sargadiols-I and -II in addition to sargasal-I, hydroxysargaquinone, kjellmanianone, and fucosterol. Among them, hydroxysargaquinone and sargasals-I and -II demonstrated significant and marginal cytotoxicity against cultured P-388 lymphocytic leukemia cells, respectively.
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收藏
页码：1209 / 1213
页数：5
相关论文
共 10 条
  • [1] SYNTHESIS AND STEREOCHEMICAL ASSIGNMENT OF CIS-AND TRANS-2-METHYL-2-PENTENOIC ACID AND CORRESPONDING ESTERS,ALDEHYDES,AND ALCOHOLS
    CHAN, KC
    JEWELL, RA
    NUTTING, WH
    RAPOPORT, H
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1968, 33 (09) : 3382 - &
  • [2] C-13-NMR - STUDY OF CIS-TRANS ISOMERIC VITAMINS-A, CAROTENOIDS AND RELATED COMPOUNDS
    ENGLERT, G
    [J]. HELVETICA CHIMICA ACTA, 1975, 58 (08) : 2367 - 2390
  • [3] KIKUCHI T, 1983, CHEM PHARM BULL, V31, P106
  • [4] C-13 NMR-SPECTRA OF DELTA-24(28) PHYTOSTEROLS
    MCINNES, AG
    WALTER, JA
    WRIGHT, JLC
    [J]. ORGANIC MAGNETIC RESONANCE, 1980, 13 (04): : 302 - 303
  • [5] STRUCTURE OF (+)-KJELLMANIANONE, A HIGHLY OXYGENATED CYCLOPENTENONE FROM THE MARIN ALGA, SARGASSUM-KJELLMANIANUM
    NAKAYAMA, M
    FUKUOKA, Y
    NOZAKI, H
    MATSUO, A
    HAYASHI, S
    [J]. CHEMISTRY LETTERS, 1980, (10) : 1243 - 1246
  • [6] NUMATA A, 1991, CHEM PHARM BULL, V39, P2129, DOI 10.1248/cpb.39.2129
  • [7] NUMATA A, 1989, CHEM PHARM BULL, V37, P648
  • [8] NUMATA A, 1987, 107TH ANN M PHARM SO, P354
  • [9] 220 MHZ PROTON NUCLEAR MAGNETIC RESONANCE SPECTRA OF RETINALS
    PATEL, DJ
    [J]. NATURE, 1969, 221 (5183) : 825 - &
  • [10] NEW PLASTOQUINONES FROM THE BROWN ALGA DESMARESTIA-MENZIESII
    RIVERA, P
    PODESTA, F
    NORTE, M
    CATALDO, F
    GONZALEZ, AG
    [J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1990, 68 (08): : 1399 - 1400
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