CENTRAL EFFECT OF YOHIMBINE ON SEXUAL-BEHAVIOR IN THE RAT

被引：35
|
作者：
SALA, M
BRAIDA, D
LEONE, MP
CALCATERRA, P
MONTI, S
GORI, E
机构：
[1] Institute of Pharmacology, Faculty of Sciences, University of Milan, Via Vanvitelli 32 /A
来源：
PHYSIOLOGY & BEHAVIOR | 1990年 / 47卷 / 01期
关键词：
Central administration; Rat; Sexual behavior; Yohimbine;
D O I：
10.1016/0031-9384(90)90057-B
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
A large range of doses of yohimbine (Y) was administered intracerebroventricularly (ICV) (5-100 μg/rat) or intraperitoneally (IP) (0.35-10 mg/kg) to male rats and the effects on sexual, locomotor and general behavior were evaluated. For both routes there was a clear-cut inverted-U effect (stimulating/depressing), calculable as parabolic regressions on the log of administered doses. The maximal stimulating doses (15 μg/rat ICV and 1 mg/kg IP) significantly shortened mount, intromission and ejaculation latencies and the mean interintromission interval. These data indicate the importance of CNS mechanisms in the sexual effect of Y. © 1990.
引用
收藏
页码：165 / 173
页数：9
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