ANTIBACTERIAL EFFICACY OF CEFAZOLIN AND CEPHRADINE IN NEUTROPENIC MICE

被引:14
作者
KUNST, MW [1 ]
MATTIE, H [1 ]
VANFURTH, R [1 ]
机构
[1] STATE UNIV LEIDEN HOSP,DEPT CLIN PHARMACOL,LEIDEN,NETHERLANDS
关键词
D O I
10.1007/BF01640554
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The activity of cefazolin (CEZ) and cephradine (CED) was studied in experimentally infected neutropenic mice. Neutropenia was induced by 600 rad whole-body irradiation; an infection was induced by the injection of 5 × 106Escherichia coli into the thigh on Day 5 after irradiation. Antibiotics were administered 1 h later, and antibacterial activity was estimated from bacteria counts made in the homogenized individual thighs 3 h after infection. The effect of a low dose of each of the cephalosporins on the infection was significantly lower in the absence of granulocytes than in animals with intact host defence; at higher dosages the effect of both antibiotics on the infection was the same in neutropenic and unirradiated mice. In the neutropenic mice, CEZ was 2.95 times more active than CED against E. coli in vivo, this difference in activity being similar to that found earlier in normal mice. © 1979 Verlagsgesellschaft Otto Spatz.
引用
收藏
页码:30 / 34
页数:5
相关论文
共 8 条
[1]  
ARMITAGE P, 1971, STATISTICAL METHODS, P444
[2]   ADVANCES IN MANAGEMENT OF PSEUDOMONAS-AERUGINOSA INFECTIONS IN CANCER-PATIENTS [J].
BODEY, GP ;
RODRIGUEZ, V .
EUROPEAN JOURNAL OF CANCER, 1973, 9 (06) :435-441
[3]  
DALE DC, 1976, BLOOD, V47, P869
[4]   EFFECT OF CLINDAMYCIN ON AMINOGLYCOSIDE ACTIVITY IN A MURINE MODEL OF INVASIVE ESCHERICHIA-COLI INFECTION [J].
EKWO, E ;
PETER, G .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (06) :893-898
[5]   CEFAZOLIN AND CEPHRADINE - RELATIONSHIP BETWEEN ANTIBACTERIAL ACTIVITY INVITRO AND IN MICE EXPERIMENTALLY INFECTED WITH ESCHERICHIA-COLI [J].
KUNST, MW ;
MATTIE, H .
JOURNAL OF INFECTIOUS DISEASES, 1978, 137 (04) :391-402
[6]   THERAPY OF NEUTROPENIC RATS INFECTED WITH PSEUDOMONAS-AERUGINOSA [J].
LUMISH, RM ;
NORDEN, CW .
JOURNAL OF INFECTIOUS DISEASES, 1976, 133 (05) :538-547
[7]  
MATTIE H, 1978, INFECTION S1, V6, P36
[8]   SYNERGISTIC ACTIVITY OF CARBENICILLIN AND GENTAMICIN IN EXPERIMENTAL PSEUDOMONAS BACTEREMIA IN NEUTROPENIC RATS [J].
SCOTT, RE ;
ROBSON, HG .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (04) :646-651