SHORT-TERM TOXICITY STUDY ON INDIGO CARMINE IN PIG

被引：26

作者：

GAUNT, IF

KISS, IS

GRASSO, P

GANGOLLI, SD

机构：

[1] Toxicology, British Industrial Biological Research Association, Carshalton, Surrey England, Woodmansterne Road

[2] Pathology, British Industrial Biological Research Association, Carshalton, Surrey England, Woodmansterne Road

[3] Analytical Chemistry British Industrial Biological Research Association, Carshalton, Surrey England, Woodmansterne Road

来源：

FOOD AND COSMETICS TOXICOLOGY | 1969年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0015-6264(69)80261-0

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Indigo Carmine was fed to pigs at levels of 0 (control), 150, 450 or 1350 mg/kg/day for 90 days. There was no effect on growth, urine and serum analyses or organ weights. A slightly reduced haemoglobin level and red-cell count was found after both 45 and 90 days in the blood of two of the three males given 1350 mg/kg. Histological examination revealed liver abscesses in one male fed Indigo Carmine at a level of 150 mg/kg/day, but this could not be attributed to the treatment given. A no-effect level of 450 mg/kg/day was therefore established. The maximum likely human intake of Indigo Carmine in the UK has been calculated as 0 · 17 mg/kg/day. © 1969 Pergamon Press Limited.

引用

页码：17 / +

页数：1