miRNA-21 as a novel therapeutic target in lung cancer

被引：91

作者：

Markou, Athina ^{[1
]}

Zavridou, Martha ^{[1
]}

Lianidou, Evi S. ^{[1
]}

机构：

[1] Univ Athens, Dept Chem, Lab Analyt Chem, Anal Circulating Tumor Cells, Athens 15771, Greece

来源：

LUNG CANCER-TARGETS AND THERAPY | 2016年 / 7卷

关键词：

lung cancer; miR-21; therapeutic target; NSCLC; response to therapy;

D O I：

10.2147/LCTT.S60341

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer is a leading cause of cancer death, and late diagnosis is one of the most important reasons for the high mortality rate. microRNAs (miRNAs) are key players in gene regulation and therefore in tumorigenesis. As far as lung carcinogenesis is concerned, miRNAs open novel fields in biomarker research, in diagnosis, and in therapy. In this review we focus on miR-21 in lung cancer and especially on how miR-21 is involved 1) as a biomarker in response or resistance to therapy or 2) as a therapeutic target.

引用

页码：19 / 27

页数：9

共 101 条

[1]

Alexius-Lindgren M, 2014, ANTICANCER RES, V34, P3867

[2] Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].

Arroyo, Jason D. ;

Chevillet, John R. ;

Kroh, Evan M. ;

Ruf, Ingrid K. ;

Pritchard, Colin C. ;

Gibson, Donald F. ;

Mitchell, Patrick S. ;

Bennett, Christopher F. ;

Pogosova-Agadjanyan, Era L. ;

Stirewalt, Derek L. ;

Tait, Jonathan F. ;

Tewari, Muneesh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008

[3] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[4] Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line [J].

Bai, Haitao ;

Xu, Rang ;

Cao, Zhongwei ;

Wei, Daolin ;

Wang, Chun .

FEBS LETTERS, 2011, 585 (02) :402-408

[5] Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR [J].

Bell, DW ;

Gore, I ;

Okimoto, RA ;

Godin-Heymann, N ;

Sordella, R ;

Mulloy, R ;

Sharma, SV ;

Brannigan, BW ;

Mohapatra, G ;

Settleman, J ;

Haber, DA .

NATURE GENETICS, 2005, 37 (12) :1315-1316

[6] MicroRNAs modulate the chemosensitivity of tumor cells [J].

Blower, Paul E. ;

Chung, Ji-Hyun ;

Verducci, Joseph S. ;

Lin, Shili ;

Park, Jong-Kook ;

Dai, Zunyan ;

Liu, Chang-Gong ;

Schmittgen, Thomas D. ;

Reinhold, William C. ;

Croce, Carlo M. ;

Weinstein, John N. ;

Sadee, Wolfgang .

MOLECULAR CANCER THERAPEUTICS, 2008, 7 (01) :1-9

[7] MicroRNA signatures in human cancers [J].

Calin, George A. ;

Croce, Carlo M. .

NATURE REVIEWS CANCER, 2006, 6 (11) :857-866

[8] Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases [J].

Chen, Xi ;

Ba, Yi ;

Ma, Lijia ;

Cai, Xing ;

Yin, Yuan ;

Wang, Kehui ;

Guo, Jigang ;

Zhang, Yujing ;

Chen, Jiangning ;

Guo, Xing ;

Li, Qibin ;

Li, Xiaoying ;

Wang, Wenjing ;

Zhang, Yan ;

Wang, Jin ;

Jiang, Xueyuan ;

Xiang, Yang ;

Xu, Chen ;

Zheng, Pingping ;

Zhang, Juanbin ;

Li, Ruiqiang ;

Zhang, Hongjie ;

Shang, Xiaobin ;

Gong, Ting ;

Ning, Guang ;

Wang, Jun ;

Zen, Ke ;

Zhang, Junfeng ;

Zhang, Chen-Yu .

CELL RESEARCH, 2008, 18 (10) :997-1006

[9] MicroRNAs in body fluids-the mix of hormones and biomarkers [J].

Cortez, Maria Angelica ;

Bueso-Ramos, Carlos ;

Ferdin, Jana ;

Lopez-Berestein, Gabriel ;

Sood, Anil K. ;

Calin, George A. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2011, 8 (08) :467-477

[10] MicroRNAs in Cancer [J].

Di Leva, Gianpiero ;

Garofalo, Michela ;

Croce, Carlo M. .

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9, 2014, 9 :287-314

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