PRODRUGS OF ANALOGS OF NUCLEIC-ACID COMPONENTS

被引:26
作者
ALEXANDER, P
HOLY, A
机构
关键词
D O I
10.1135/cccc19942127
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This review regards various attitudes to the rational design of prodrugs derived of nucleoside and nucleotide analogues with pronounced biological (antiviral, anticancer) activity. Particular attention is focused on the recent development of prodrugs of approved therapeutic agents with the above structural association.
引用
收藏
页码:2127 / 2165
页数:39
相关论文
共 213 条
[1]   SYNTHESIS AND BIOLOGICAL EVALUATION OF PRODRUGS OF ZIDOVUDINE [J].
AGGARWAL, SK ;
GOGU, SR ;
RANGAN, SRS ;
AGRAWAL, KC .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) :1505-1510
[2]   CHEMICAL ASPECTS OF SELECTIVE TOXICITY [J].
ALBERT, A .
NATURE, 1958, 182 (4633) :421-423
[3]  
AOSHIMA M, 1976, CANCER RES, V36, P2726
[4]  
AU JL, 1979, CANCER RES, V39, P4289
[5]  
AU JLS, 1980, CANCER RES, V40, P2814
[6]   NEW APPROACHES TO THE DELIVERY OF DRUGS TO THE BRAIN [J].
AYRE, SG .
MEDICAL HYPOTHESES, 1989, 29 (04) :283-291
[7]  
Bacon T. H., 1994, Antiviral Research, V23, P99
[8]   AN OVERVIEW OF THE FURTHER EVALUATION OF PENCICLOVIR AGAINST HERPES-SIMPLEX VIRUS AND VARICELLA-ZOSTER VIRUS IN CELL-CULTURE HIGHLIGHTING CONTRASTS WITH ACYCLOVIR [J].
BACON, TH ;
SCHINAZI, RF .
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1993, 4 :25-36
[9]   PRODRUGS OF 9-(BETA-D-ARABINOFURANOSYL)ADENINE .2. SYNTHESIS AND EVALUATION OF A NUMBER OF 2',3'-DI-O-ACYL DERIVATIVES AND 3',5'-DI-O-ACYL DERIVATIVES [J].
BAKER, DC ;
HASKELL, TH ;
PUTT, SR ;
SLOAN, BJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (03) :273-279
[10]   ESTIMATION OF THE LIPOPHILICITY OF ANTI-HIV NUCLEOSIDE ANALOGS BY DETERMINATION OF THE PARTITION-COEFFICIENT AND RETENTION TIME ON A LICHROSPHER-60 RP-8 HPLC COLUMN [J].
BALZARINI, J ;
COOLS, M ;
DECLERCQ, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 158 (02) :413-422