TRANSBRONCHIAL BIOPSY IN LYMPHANGIOMYOMATOSIS OF THE LUNG - HMB45 FOR DIAGNOSIS

被引：158

作者：

BONETTI, F

CHIODERA, PL

PEA, M

MARTIGNONI, G

BOSI, F

ZAMBONI, G

MARIUZZI, GM

机构：

[1] OSPED VALLECAMON,SERV ANAT PATOL,BRESCIA,ITALY

[2] UNIV PAVIA,DIPARTIMENTO PATOL UMANA & EREDITARIA,PAVIA,ITALY

来源：

AMERICAN JOURNAL OF SURGICAL PATHOLOGY | 1993年 / 17卷 / 11期

关键词：

LYMPHANGIOMYOMATOSIS; HMB45; TUBEROUS SCLEROSIS; IMMUNOHISTOCHEMISTRY; MELANOMA MARKER;

D O I：

10.1097/00000478-199311000-00002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We have investigated the presence of smooth muscle cells with immunoreactivity for melanoma-related marker HMB45 in pulmonary lymphangiomyomatosis (PLAM). Of 75 lung specimens, including a variety of lesions (obtained with both transbronchial and open lung biopsies), only PLAM (six specimens from three patients) showed the presence of HMB45-positive cells. In addition, 20 specimens of normal lung were unreactive with this monoclonal antibody. It is concluded that the smooth muscle cells of PLAM regularly exhibit a peculiar phenotype, characterized by HMB45 immunoreactivity, distinct from other smooth muscle proliferations; and the histological diagnosis of PLAM can be made when only a transbronchial biopsy is available.

引用

页码：1092 / 1102

页数：11

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