INHIBITION OF AMINOPEPTIDASES BY PHOSPHONIC ACID AND PHOSPHINIC ACID ANALOGS OF ASPARTIC AND GLUTAMIC ACIDS

被引：22

作者：

LEJCZAK, B

DECHOSZCZAK, MP

KAFARSKI, P

机构：

[1] Institute of Organic and Physical Chemistry, Technical University of Wroclaw, 50-370 Wroclaw

来源：

JOURNAL OF ENZYME INHIBITION | 1993年 / 7卷 / 02期

关键词：

CYTOSOLIC AMINOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE; LAP; APM; PHOSPHONIC ACIDS; PHOSPHINIC ACIDS;

D O I：

10.3109/14756369309040752

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

More than 30 phosphonic and phosphinic acid analogues of aspartic and glutamic acids were synthesized in order to probe how the structural differences of these molecules were reflected in their ability to inhibit cytosolic (LAP) and microsomal (APM) aminopeptidases. Although most of the compounds studied were found to exert only a modest inhibitory effect, the studies provide some information on the structural requirements of the binding subsites and catalytic centers of both enzymes.

引用

页码：97 / 103

页数：7

共 16 条

[1] ALPHA-AMINOALDEHYDES - TRANSITION-STATE ANALOG INHIBITORS OF LEUCINE AMINOPEPTIDASE [J].