PAPILLOMAS AND CARCINOMAS IN TRANSGENIC RABBITS CARRYING EJ-RAS DNA AND COTTONTAIL RABBIT PAPILLOMAVIRUS DNA

被引：17

作者：

PENG, XW

OLSON, RO

CHRISTIAN, CB

LANG, CM

KREIDER, JW

机构：

[1] PENN STATE UNIV, MILTON S HERSHEY MED CTR, DEPT PATHOL, HERSHEY, PA 17033 USA

[2] PENN STATE UNIV, MILTON S HERSHEY MED CTR, DEPT COMPARAT MED, HERSHEY, PA 17033 USA

[3] PENN STATE UNIV, MILTON S HERSHEY MED CTR, DEPT MICROBIOL & IMMUNOL, HERSHEY, PA 17033 USA

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 03期

关键词：

D O I：

10.1128/JVI.67.3.1698-1701.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two transgenic rabbits (TRI and TRIII) that carried cottontail rabbit papillomavirus (CRPV) DNA alone were identified; another (TRII) carried both CRPV DNA and EJ-ras. TRI and TRIII developed extensive skin papillomas at about 1 month of age, and transcripts of CRPV DNA were detectable only in skin and/or papillomas. TRII developed extensive squamous carcinomas of the skin at a very early age. Transcription of both CRPV DNA and EJ-ras was found in the skin cancers. Thus, the tissue specificity of CRPV DNA expression in transgenic rabbits was the same as in virion-infected animals. The expression of EJ-ras could be dependent on the expression of certain CRPV genes and may be a critical cofactor of CRPV DNA in the progression of carcinomas.

引用

页码：1698 / 1701

页数：4

共 26 条

[1]

BUHLER TA, 1990, BIO-TECHNOL, V8, P140, DOI 10.1038/nbt0290-140

[2] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].