SMOKING INFLUENCES THE ATHEROGENIC POTENTIAL OF LOW-DENSITY-LIPOPROTEIN

被引：0
|
作者：
SCHEFFLER, E
WIEST, E
WOEHRLE, J
OTTO, I
SCHULZ, I
HUBER, L
ZIEGLER, R
DRESEL, HA
机构：
[1] UNIV HEIDELBERG, MED KLIN, W-6900 HEIDELBERG, GERMANY
[2] BOEHRINGER MANNHEIM GMBH, ARTERIOSKLEROSEFORSCH ABT, W-6800 MANNHEIM, GERMANY
来源：
CLINICAL INVESTIGATOR | 1992年 / 70卷 / 3-4期
关键词：
LOW-DENSITY LIPOPROTEIN; VITAMIN-E; SMOKING; LIPID PEROXIDATION; ATHEROSCLEROSIS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The possible influence of smoking on the low-density lipoprotein (LDL) and its biological activity was investigated. Plasma LDL was prepared from healthy male smokers and nonsmokers, and oxidized with Cu (11) as prooxidant. Oxidized LDL from smokers generated significantly more lipid-peroxidation products, so-called thiobarbituric acid reactive substances (TBARS), when compared to oxidized nonsmoker LDL. Analysis of vitamin E levels in LDL obtained from both smokers and nonsmokers revealed that the vitamin E content of smoker LDL was significantly less than that of nonsmoker LDL. The amounts of cholesteryl esters formed in cultured P388. D.1 macrophages were greater in the presence of smoker LDL than with nonsmoker LDL. The data suggest that some of the proatherogenic effects of smoking may be related to oxidative modification of LDL and alteration of its biological activity.
引用
收藏
页码：263 / 268
页数：6
相关论文
共 50 条
  • [31] Atherogenic low-density lipoprotein and cardiovascular risk
    Hernando-Redondo, Javier
    Nino, Olga Castaner
    Fito, Montse
    CURRENT OPINION IN LIPIDOLOGY, 2025, 36 (01) : 8 - 13
  • [32] NMR ANALYSIS OF LOW-DENSITY-LIPOPROTEIN OXIDATIVELY-MODIFIED INVITRO
    BARENGHI, L
    BRADAMANTE, S
    GIUDICI, GA
    VERGANI, C
    FREE RADICAL RESEARCH COMMUNICATIONS, 1990, 8 (03): : 175 - 183
  • [33] THE EFFECT OF GENETIC-DETERMINANTS OF LOW-DENSITY-LIPOPROTEIN LEVELS ON LIPOPROTEIN (A)
    HEGELE, RA
    SUTHERLAND, S
    ROBERTSON, M
    WU, L
    EMI, M
    HOPKINS, PN
    WILLIAMS, RR
    LALOUEL, JM
    CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE, 1991, 14 (02): : 146 - 152
  • [34] ACIDIC PH ENABLES CERULOPLASMIN TO CATALYZE THE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN
    LAMB, DJ
    LEAKE, DS
    FEBS LETTERS, 1994, 338 (02) : 122 - 126
  • [35] OXIDATIVE MODIFICATION AND ANTIOXIDANT PROTECTION OF HUMAN LOW-DENSITY-LIPOPROTEIN AT HIGH AND LOW-OXYGEN PARTIAL PRESSURES
    HATTA, A
    FREI, B
    JOURNAL OF LIPID RESEARCH, 1995, 36 (11) : 2383 - 2393
  • [36] ENHANCED SUSCEPTIBILITY TO INVITRO OXIDATION OF THE DENSE LOW-DENSITY-LIPOPROTEIN SUBFRACTION IN HEALTHY-SUBJECTS
    DEGRAAF, J
    HAKLEMMERS, HLM
    HECTORS, MPC
    DEMACKER, PNM
    HENDRIKS, JCM
    STALENHOEF, AFH
    ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (02): : 298 - 306
  • [37] DETERMINATION OF LIPID HYDROPEROXIDES IN NATIVE LOW-DENSITY-LIPOPROTEIN BY A CHEMILUMINESCENT FLOW-INJECTION ASSAY
    COMINACINI, L
    PASTORINO, AM
    MCCARTHY, A
    CAMPAGNOLA, M
    GARBIN, U
    DAVOLI, A
    DESANTIS, A
    LOCASCIO, V
    BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1165 (03) : 279 - 287
  • [38] STRUCTURAL REQUIREMENTS FOR OXIDATION OF LOW-DENSITY-LIPOPROTEIN BY THIOLS
    WOOD, JL
    GRAHAM, A
    FEBS LETTERS, 1995, 366 (01) : 75 - 80
  • [39] INHIBITION OF OXIDATIVE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN BY ANTIOXIDANTS
    NIKI, E
    NOGUCHI, N
    GOTOH, N
    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 1993, 39 : S1 - S8
  • [40] EVALUATION OF METHODS FOR COMPLEXING PREDNIMUSTINE TO LOW-DENSITY-LIPOPROTEIN
    LUNDBERG, BB
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1993, 99 (2-3) : 275 - 283
12345