ENZYMES OF LYSOSOMAL ORIGIN IN THE CEREBROSPINAL-FLUID AND PLASMA OF PATIENTS WITH MULTIPLE-SCLEROSIS

被引：4

作者：

GOI, G

CAPUTO, D

BAIRATI, C

LOMBARDO, A

BURLINA, AB

FERRANTE, P

CAZZULLO, CL

TETTAMANTI, G

机构：

[1] UNIV MILAN,CTR SCLEROSI MULTIPLA DON GNOCCHI,VIA CAPECELATRO 66,I-20148 MILAN,ITALY

[2] UNIV MILAN,DEPT MED CHEM & BIOCHEM,I-20122 MILAN,ITALY

来源：

EUROPEAN NEUROLOGY | 1993年 / 33卷 / 01期

关键词：

LYSOSOMAL ENZYMES; CEREBROSPINAL FLUID; PLASMA; MULTIPLE SCLEROSIS;

D O I：

10.1159/000116888

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Several lysosomal enzymes were determined in 47 and 62 samples of CSF and plasma, respectively, obtained from MS patients. CSF levels of most enzymes considered were significantly lower in patients when compared to those of the controls, whereas the plasma levels vary little and appeared to be influenced by the course of the disease. The most interesting result is the one concerning the beta-D-glucuronidase in the plasma: in relapsing-remitting patients in the still untreated acute phase, the levels remain noticeably diminished in comparison to controls. The data suggest the potential of using this enzyme to monitor the progression of the disease.

引用

页码：1 / 4

页数：4

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