5-HT3 RECEPTOR ANTAGONISTS REVERSE HELPLESS BEHAVIOR IN RATS

被引：65
|
作者：
MARTIN, P
GOZLAN, H
PUECH, AJ
机构：
[1] UNIV PARIS 06,DEPT PHARMACOL,F-75634 PARIS 13,FRANCE
[2] UNIV PARIS 06,INSERM,U288,F-75634 PARIS 13,FRANCE
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 212卷 / 01期
关键词：
5-HT3 RECEPTOR ANTAGONISTS; LEARNED HELPLESSNESS PARADIGM; (RAT);
D O I：
10.1016/0014-2999(92)90074-E
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of the 5-HT3 receptor antagonists, zacopride, ondansetron and ICS 205-930, were investigated in an animal model of depression, the learned helplessness test. Rats previously subjected to a session of 60 inescapable foot-shocks exhibited a deficit of escape performance in three subsequent shuttle-box sessions. The 5-HT3 receptor antagonists administered i.p. twice daily on a chronic schedule (zacopride 0.03-2 mg/kg per day; ondansetron and ICS 205-930: 0.125-2 mg/kg per day) reduced the number of escape failures at low to moderate daily doses. This effect was not observed with the highest dose(s) of zacopride, ondansetron and ICS 205-930 tested. These results indicate that 5-HT3 antagonists may have effects like those of conventional antidepressants in rats.
引用
收藏
页码：73 / 78
页数：6
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